PittsburghV1, Main, Exploration, bibRecord, 003154

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

Identifieur interne : 003154 ( Main/Exploration ); précédent : 003153; suivant : 003155

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

Auteurs : Mario Castro [États-Unis] ; Tonya S. King [États-Unis] ; Susan J. Kunselman [États-Unis] ; Michael D. Cabana [États-Unis] ; Loren Denlinger ; Fernando Holguin [États-Unis] ; Shamsah D. Kazani [États-Unis] ; Wendy C. Moore [États-Unis] ; James Moy [États-Unis] ; Christine A. Sorkness ; Pedro Avila [États-Unis] ; Leonard B. Bacharier [États-Unis] ; Eugene Bleecker [États-Unis] ; Homer A. Boushey [États-Unis] ; James Chmiel [États-Unis] ; Anne M. Fitzpatrick [Géorgie (pays)] ; Deborah Gentile [États-Unis] ; Mandeep Hundal [États-Unis] ; Elliot Israel [États-Unis] ; Monica Kraft [États-Unis] ; Jerry A. Krishnan [États-Unis] ; Craig Laforce ; Stephen C. Lazarus [États-Unis] ; Robert Lemanske ; Njira Lugogo [États-Unis] ; Richard J. Martin [États-Unis] ; David T. Mauger [États-Unis] ; Edward Naureckas [États-Unis] ; Stephen P. Peters [États-Unis] ; Wanda Phipatanakul [États-Unis] ; Loretta G. Que [États-Unis] ; Ajay Sheshadri [États-Unis] ; Lewis Smith [États-Unis] ; Julian Solway [États-Unis] ; Lisa Sullivan-Vedder [États-Unis] ; Kaharu Sumino [États-Unis] ; Michael E. Wechsler [États-Unis] ; Sally Wenzel [États-Unis] ; Steven R. White [États-Unis] ; E Rand Sutherland

Source :

JAMA [ 1538-3598 ] ; 2014.

RBID : pubmed:24838406

Descripteurs français

KwdFr :
- Administration par inhalation, Administration par voie orale, Adulte, Adulte d'âge moyen, Antiasthmatiques (administration et posologie), Asthme (), Asthme (physiopathologie), Asthme (traitement médicamenteux), Carence en vitamine D (), Carence en vitamine D (traitement médicamenteux), Cholécalciférol (usage thérapeutique), Femelle, Glucocorticoïdes (administration et posologie), Hormones corticosurrénaliennes (administration et posologie), Humains, Mâle, Méthode en double aveugle, Poumon (), Poumon (physiopathologie), Prégnènediones (administration et posologie), Relation dose-effet des médicaments, Vitamines (usage thérapeutique), Échec thérapeutique.
MESH :
- administration et posologie : Antiasthmatiques, Glucocorticoïdes, Hormones corticosurrénaliennes, Prégnènediones.
- physiopathologie : Asthme, Poumon.
- traitement médicamenteux : Asthme, Carence en vitamine D.
- usage thérapeutique : Cholécalciférol, Vitamines.
- Administration par inhalation, Administration par voie orale, Adulte, Adulte d'âge moyen, Asthme, Carence en vitamine D, Femelle, Humains, Mâle, Méthode en double aveugle, Poumon, Relation dose-effet des médicaments, Échec thérapeutique.

English descriptors

KwdEn :
- Administration, Inhalation, Administration, Oral, Adrenal Cortex Hormones (administration & dosage), Adult, Anti-Asthmatic Agents (administration & dosage), Asthma (complications), Asthma (drug therapy), Asthma (physiopathology), Cholecalciferol (therapeutic use), Dose-Response Relationship, Drug, Double-Blind Method, Female, Glucocorticoids (administration & dosage), Humans, Lung (drug effects), Lung (physiopathology), Male, Middle Aged, Pregnenediones (administration & dosage), Treatment Failure, Vitamin D Deficiency (complications), Vitamin D Deficiency (drug therapy), Vitamins (therapeutic use).
MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Anti-Asthmatic Agents, Glucocorticoids, Pregnenediones.
- complications : Asthma, Vitamin D Deficiency.
- drug effects : Lung.
- drug therapy : Asthma, Vitamin D Deficiency.
- physiopathology : Asthma, Lung.
- chemical , therapeutic use : Cholecalciferol, Vitamins.
- Administration, Inhalation, Administration, Oral, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Failure.

Abstract

In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency.

DOI: 10.1001/jama.2014.5052
PubMed: 24838406

Affiliations:

Le document en format XML

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<author><name sortKey="Smith, Lewis" sort="Smith, Lewis" uniqKey="Smith L" first="Lewis" last="Smith">Lewis Smith</name>
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<author><name sortKey="Solway, Julian" sort="Solway, Julian" uniqKey="Solway J" first="Julian" last="Solway">Julian Solway</name>
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</author>
<author><name sortKey="Sullivan Vedder, Lisa" sort="Sullivan Vedder, Lisa" uniqKey="Sullivan Vedder L" first="Lisa" last="Sullivan-Vedder">Lisa Sullivan-Vedder</name>
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<author><name sortKey="Wechsler, Michael E" sort="Wechsler, Michael E" uniqKey="Wechsler M" first="Michael E" last="Wechsler">Michael E. Wechsler</name>
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<author><name sortKey="Wenzel, Sally" sort="Wenzel, Sally" uniqKey="Wenzel S" first="Sally" last="Wenzel">Sally Wenzel</name>
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<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea>
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<author><name sortKey="White, Steven R" sort="White, Steven R" uniqKey="White S" first="Steven R" last="White">Steven R. White</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>University of Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sutherland, E Rand" sort="Sutherland, E Rand" uniqKey="Sutherland E" first="E Rand" last="Sutherland">E Rand Sutherland</name>
<affiliation><nlm:affiliation>National Jewish Health, Denver, Colorado20Dr Sutherland is now with sanofi.</nlm:affiliation>
<wicri:noCountry code="subField">Colorado20Dr Sutherland is now with sanofi</wicri:noCountry>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.</title>
<author><name sortKey="Castro, Mario" sort="Castro, Mario" uniqKey="Castro M" first="Mario" last="Castro">Mario Castro</name>
<affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="King, Tonya S" sort="King, Tonya S" uniqKey="King T" first="Tonya S" last="King">Tonya S. King</name>
<affiliation wicri:level="2"><nlm:affiliation>Penn State University, Hershey, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Penn State University, Hershey</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kunselman, Susan J" sort="Kunselman, Susan J" uniqKey="Kunselman S" first="Susan J" last="Kunselman">Susan J. Kunselman</name>
<affiliation wicri:level="2"><nlm:affiliation>Penn State University, Hershey, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Penn State University, Hershey</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cabana, Michael D" sort="Cabana, Michael D" uniqKey="Cabana M" first="Michael D" last="Cabana">Michael D. Cabana</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Denlinger, Loren" sort="Denlinger, Loren" uniqKey="Denlinger L" first="Loren" last="Denlinger">Loren Denlinger</name>
<affiliation><nlm:affiliation>University of Wisconsin, Madison.</nlm:affiliation>
<wicri:noCountry code="subField">Madison</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Holguin, Fernando" sort="Holguin, Fernando" uniqKey="Holguin F" first="Fernando" last="Holguin">Fernando Holguin</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kazani, Shamsah D" sort="Kazani, Shamsah D" uniqKey="Kazani S" first="Shamsah D" last="Kazani">Shamsah D. Kazani</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moore, Wendy C" sort="Moore, Wendy C" uniqKey="Moore W" first="Wendy C" last="Moore">Wendy C. Moore</name>
<affiliation wicri:level="2"><nlm:affiliation>Wake Forest School of Medicine, Winston-Salem, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Wake Forest School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moy, James" sort="Moy, James" uniqKey="Moy J" first="James" last="Moy">James Moy</name>
<affiliation wicri:level="2"><nlm:affiliation>Stroger Hospital of Cook County, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Stroger Hospital of Cook County, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sorkness, Christine A" sort="Sorkness, Christine A" uniqKey="Sorkness C" first="Christine A" last="Sorkness">Christine A. Sorkness</name>
<affiliation><nlm:affiliation>University of Wisconsin, Madison.</nlm:affiliation>
<wicri:noCountry code="subField">Madison</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Avila, Pedro" sort="Avila, Pedro" uniqKey="Avila P" first="Pedro" last="Avila">Pedro Avila</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bacharier, Leonard B" sort="Bacharier, Leonard B" uniqKey="Bacharier L" first="Leonard B" last="Bacharier">Leonard B. Bacharier</name>
<affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bleecker, Eugene" sort="Bleecker, Eugene" uniqKey="Bleecker E" first="Eugene" last="Bleecker">Eugene Bleecker</name>
<affiliation wicri:level="2"><nlm:affiliation>Wake Forest School of Medicine, Winston-Salem, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Wake Forest School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boushey, Homer A" sort="Boushey, Homer A" uniqKey="Boushey H" first="Homer A" last="Boushey">Homer A. Boushey</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Chmiel, James" sort="Chmiel, James" uniqKey="Chmiel J" first="James" last="Chmiel">James Chmiel</name>
<affiliation wicri:level="2"><nlm:affiliation>Rainbow Babies and Children's Hospital, Cleveland, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Rainbow Babies and Children's Hospital, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, Anne M" sort="Fitzpatrick, Anne M" uniqKey="Fitzpatrick A" first="Anne M" last="Fitzpatrick">Anne M. Fitzpatrick</name>
<affiliation wicri:level="1"><nlm:affiliation>Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gentile, Deborah" sort="Gentile, Deborah" uniqKey="Gentile D" first="Deborah" last="Gentile">Deborah Gentile</name>
<affiliation wicri:level="2"><nlm:affiliation>Allegheny General Hospital, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Allegheny General Hospital, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hundal, Mandeep" sort="Hundal, Mandeep" uniqKey="Hundal M" first="Mandeep" last="Hundal">Mandeep Hundal</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Israel, Elliot" sort="Israel, Elliot" uniqKey="Israel E" first="Elliot" last="Israel">Elliot Israel</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Monica" sort="Kraft, Monica" uniqKey="Kraft M" first="Monica" last="Kraft">Monica Kraft</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Krishnan, Jerry A" sort="Krishnan, Jerry A" uniqKey="Krishnan J" first="Jerry A" last="Krishnan">Jerry A. Krishnan</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Illinois, Chicago.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<wicri:orgArea>University of Illinois</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Laforce, Craig" sort="Laforce, Craig" uniqKey="Laforce C" first="Craig" last="Laforce">Craig Laforce</name>
<affiliation><nlm:affiliation>North Carolina Clinical Research, Raleigh.</nlm:affiliation>
<wicri:noCountry code="subField">Raleigh</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lazarus, Stephen C" sort="Lazarus, Stephen C" uniqKey="Lazarus S" first="Stephen C" last="Lazarus">Stephen C. Lazarus</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Lemanske, Robert" sort="Lemanske, Robert" uniqKey="Lemanske R" first="Robert" last="Lemanske">Robert Lemanske</name>
<affiliation><nlm:affiliation>University of Wisconsin, Madison.</nlm:affiliation>
<wicri:noCountry code="subField">Madison</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lugogo, Njira" sort="Lugogo, Njira" uniqKey="Lugogo N" first="Njira" last="Lugogo">Njira Lugogo</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Martin, Richard J" sort="Martin, Richard J" uniqKey="Martin R" first="Richard J" last="Martin">Richard J. Martin</name>
<affiliation wicri:level="2"><nlm:affiliation>National Jewish Health, Denver, Colorado.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>National Jewish Health, Denver</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mauger, David T" sort="Mauger, David T" uniqKey="Mauger D" first="David T" last="Mauger">David T. Mauger</name>
<affiliation wicri:level="2"><nlm:affiliation>Penn State University, Hershey, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Penn State University, Hershey</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Naureckas, Edward" sort="Naureckas, Edward" uniqKey="Naureckas E" first="Edward" last="Naureckas">Edward Naureckas</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>University of Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peters, Stephen P" sort="Peters, Stephen P" uniqKey="Peters S" first="Stephen P" last="Peters">Stephen P. Peters</name>
<affiliation wicri:level="2"><nlm:affiliation>Wake Forest School of Medicine, Winston-Salem, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Wake Forest School of Medicine, Winston-Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Phipatanakul, Wanda" sort="Phipatanakul, Wanda" uniqKey="Phipatanakul W" first="Wanda" last="Phipatanakul">Wanda Phipatanakul</name>
<affiliation wicri:level="2"><nlm:affiliation>Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston Children's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Que, Loretta G" sort="Que, Loretta G" uniqKey="Que L" first="Loretta G" last="Que">Loretta G. Que</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sheshadri, Ajay" sort="Sheshadri, Ajay" uniqKey="Sheshadri A" first="Ajay" last="Sheshadri">Ajay Sheshadri</name>
<affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Smith, Lewis" sort="Smith, Lewis" uniqKey="Smith L" first="Lewis" last="Smith">Lewis Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Solway, Julian" sort="Solway, Julian" uniqKey="Solway J" first="Julian" last="Solway">Julian Solway</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>University of Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sullivan Vedder, Lisa" sort="Sullivan Vedder, Lisa" uniqKey="Sullivan Vedder L" first="Lisa" last="Sullivan-Vedder">Lisa Sullivan-Vedder</name>
<affiliation wicri:level="2"><nlm:affiliation>Aurora Sinai Medical Center, Milwaukee, Wisconsin.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Aurora Sinai Medical Center, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sumino, Kaharu" sort="Sumino, Kaharu" uniqKey="Sumino K" first="Kaharu" last="Sumino">Kaharu Sumino</name>
<affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wechsler, Michael E" sort="Wechsler, Michael E" uniqKey="Wechsler M" first="Michael E" last="Wechsler">Michael E. Wechsler</name>
<affiliation wicri:level="2"><nlm:affiliation>National Jewish Health, Denver, Colorado.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>National Jewish Health, Denver</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wenzel, Sally" sort="Wenzel, Sally" uniqKey="Wenzel S" first="Sally" last="Wenzel">Sally Wenzel</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Steven R" sort="White, Steven R" uniqKey="White S" first="Steven R" last="White">Steven R. White</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>University of Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sutherland, E Rand" sort="Sutherland, E Rand" uniqKey="Sutherland E" first="E Rand" last="Sutherland">E Rand Sutherland</name>
<affiliation><nlm:affiliation>National Jewish Health, Denver, Colorado20Dr Sutherland is now with sanofi.</nlm:affiliation>
<wicri:noCountry code="subField">Colorado20Dr Sutherland is now with sanofi</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA</title>
<idno type="eISSN">1538-3598</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation</term>
<term>Administration, Oral</term>
<term>Adrenal Cortex Hormones (administration & dosage)</term>
<term>Adult</term>
<term>Anti-Asthmatic Agents (administration & dosage)</term>
<term>Asthma (complications)</term>
<term>Asthma (drug therapy)</term>
<term>Asthma (physiopathology)</term>
<term>Cholecalciferol (therapeutic use)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Glucocorticoids (administration & dosage)</term>
<term>Humans</term>
<term>Lung (drug effects)</term>
<term>Lung (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pregnenediones (administration & dosage)</term>
<term>Treatment Failure</term>
<term>Vitamin D Deficiency (complications)</term>
<term>Vitamin D Deficiency (drug therapy)</term>
<term>Vitamins (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par inhalation</term>
<term>Administration par voie orale</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiasthmatiques (administration et posologie)</term>
<term>Asthme ()</term>
<term>Asthme (physiopathologie)</term>
<term>Asthme (traitement médicamenteux)</term>
<term>Carence en vitamine D ()</term>
<term>Carence en vitamine D (traitement médicamenteux)</term>
<term>Cholécalciférol (usage thérapeutique)</term>
<term>Femelle</term>
<term>Glucocorticoïdes (administration et posologie)</term>
<term>Hormones corticosurrénaliennes (administration et posologie)</term>
<term>Humains</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Poumon ()</term>
<term>Poumon (physiopathologie)</term>
<term>Prégnènediones (administration et posologie)</term>
<term>Relation dose-effet des médicaments</term>
<term>Vitamines (usage thérapeutique)</term>
<term>Échec thérapeutique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term>
<term>Anti-Asthmatic Agents</term>
<term>Glucocorticoids</term>
<term>Pregnenediones</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiasthmatiques</term>
<term>Glucocorticoïdes</term>
<term>Hormones corticosurrénaliennes</term>
<term>Prégnènediones</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Asthma</term>
<term>Vitamin D Deficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term>
<term>Vitamin D Deficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Asthme</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cholecalciferol</term>
<term>Vitamins</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Asthme</term>
<term>Carence en vitamine D</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cholécalciférol</term>
<term>Vitamines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Inhalation</term>
<term>Administration, Oral</term>
<term>Adult</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Failure</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par inhalation</term>
<term>Administration par voie orale</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Asthme</term>
<term>Carence en vitamine D</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Poumon</term>
<term>Relation dose-effet des médicaments</term>
<term>Échec thérapeutique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency.</div>
</front>
</TEI>
<affiliations><list><country><li>Géorgie (pays)</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Colorado</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Missouri (État)</li>
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   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
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   |clé=     pubmed:24838406
   |texte=   Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
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Serveur d'exploration sur Pittsburgh

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

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